If the sealer is applied correctly, then no it doesn't need to be wet sanded. This assumes that the sealer is applied just prior to the paint. You can't spray the sealer one weekend and then expect to paint the top coat the next weekend.....
However, there's always an exception. In the case of my RS, I had a few drips of sealer (from the air hole on the top of my spray gun) on the driver side rear quarter
. So I waited for the sealer to setup, wetsanded it smooth and then re-applied one final coat of sealer on that panel prior to paint. If I didn't FUBAR that panel, I would have went straight from sealer to base color coat.
That's one thing you have to sort of expect if you do this as a hobby (ie not as a professional). There will always be issues, mistakes, etc. Take your time, deal with them as they come and it will all work out in the end
The other thing I recommend is to practice. Go get a used fender, etc and practice the full process of prep, paint, etc before tackling an entire car. It's easier and less costly if you make a mistake.
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